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Il y a 3 jours · Laurent Dupuis, 45, of Deux-Montagnes, 40 kilometres west of Montreal, was first prescribed opioids at age 18 for a torn ACL in his left knee. He had several surgeries for that injury and others ...
Il y a 7 heures · Knowing it faces an uphill battle commercially, the company last year boosted its lobbying spending almost 50%, to more than $3 million. Vertex is pressing Congress for new policies that remove ...
Il y a 1 jour · Opioids have long been known as natural substances with substantial pharmacological effects and have been used as effective painkillers. A very prominent example is morphine, which was first ...
Il y a 16 heures · Most opioid painkillers work by targeting the μ-opioid receptor (MOR) located on nerve cells in the brain, spinal cord, and other places in the body. But in addition to providing pain relief, this mode of action also gives rise to side effects. Now, a team led by Ichio Shimada of the RIKEN Center for Biosystems Dynamics Research (BDR) has ...
Il y a 4 jours · Morphine is used primarily to treat both acute and chronic severe pain. Its duration of analgesia is about three to seven hours. [12] [13] Side-effects of nausea and constipation are rarely severe enough to warrant stopping treatment. It is used for pain due to myocardial infarction and for labor pains. [12]
Il y a 16 heures · Fentanyl contamination in cocaine, methamphetamine, ketamine, MDMA, and other drugs is common. [89] [90] A kilogram of heroin laced with fentanyl may sell for more than US$100,000, but the fentanyl itself may be produced far more cheaply, for about US$6,000 per kilogram.
Il y a 3 jours · New research could transform how we understand the way opioids affect the brain. Despite significant discussion surrounding the ongoing opioid crisis, current understanding of how opioids function ...
