Résultats de recherche
31 mars 2021 · Here, we reconstitute the selective behaviour of the NPC bottom-up by introducing a rationally designed artificial FG-Nup that mimics natural Nups.
26 avr. 2023 · The FG-NUPs form a permeability barrier in the central channel of the NPC, which regulates nucleocytoplasmic transport by restricting the passage of large cargo unless it presents a nuclear...
31 mars 2021 · Here, we reconstitute the selective behaviour of the NPC bottom-up by introducing a rationally designed artificial FG-Nup that mimics natural Nups. Using QCM-D, we measure selective binding of the artificial FG-Nup brushes to the transport receptor Kap95 over cytosolic proteins such as BSA.
17 août 2021 · Nucleocytoplasmic transport is vital for the cell and is mainly regulated by intrinsically disordered proteins named FG nucleoporins (FG Nups). These proteins are named FG Nups because they are rich in phenylalanine-glycine repeats. FG Nups enable fast, yet selective, transport through the NPC.
27 oct. 2022 · The FG-Nups are intrinsically disordered and prone to liquid–liquid phase separation and aggregation when isolated. How FG-Nups are protected from making inappropriate interactions during NPC...
17 août 2021 · Previously, we identified an evolutionarily conserved feature in FG Nup sequences, which are extended subsequences with low charge density, containing only positive charges, and located toward the N-terminus of FG Nups. We named these patterns longest positive like charge regions (lpLCRs).
31 mars 2021 · Here, we reconstitute the selective behaviour of the NPC bottom-up by introducing a rationally designed artificial FG-Nup that mimics natural Nups.
