Résultats de recherche
1 oct. 2010 · Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two WD-40 domain proteins, Cdc20 and Cdh1.
- The function of APC/CCdh1 in cell cycle and beyond - PubMed
The anaphase promoting complex/cyclosome (APC/C) is a...
- The function of APC/CCdh1 in cell cycle and beyond - PubMed
19 janv. 2009 · In addition, APC Cdh1 is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APC Cdh1 function in cell cycle and beyond.
Cdh1 is one of the co- activator proteins of APC/c and therefore contributes to the regulation of protein degradation, by providing substrate specificity to the E3-ligase in a cell cycle regulated manner.
7 juin 2019 · In the G2 and M phases after DNA synthesis, expression of the APC/C adaptor CDH1 allows APC/CCDH1 to degrade D-box-containing TKTL1, abrogating ribose-5-phosphate accumulation by TKTL1.
21 sept. 2004 · Global roles for APC/C and SCF1 in the core cell cycle. Green denotes activation or inhibition that promotes cell cycle progression, whereas red indicates activities that block progression. APC/C substrates are in orange letters, and SCF1 substrates in blue.
19 janv. 2009 · The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates.
11 oct. 2010 · APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. Qiao X1, Zhang L, Gamper AM, Fujita T, Wan Y. Author information. Affiliations. 1 author. 1. Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
